Disclosure of the Mechanisms of Metabolic Disorders in Highly Productive Cows as a Way to Improve Milk Production Technology

The aim of this study was to the molecular mechanisms metabolic disorders that develop in highly productive cows. It found blood serum animals with subclinical ketosis (SCK), which are eighth month pregnancy, concentration β-hydroxybutyrate is increased, content iron, calcium and phosphorus reduced, its iron-binding capacity against background absence phenomena hepatocellular insufficiency, violation integrity hepatocytes, hypoplastic anemia. aggravation ketoacidosis fresh cows rumen acidosis facilitated by development carbohydrate deficiency them, due their increased oxidation reactions anaerobic glycolysis, accompanied excessive catabolism purine mononucleotides uric acid. Excessive lipid peroxidation membrane structures under conditions nucleotides, along accumulation acylglycerols liver caused cobalamin deficiency, leads syndromes impaired hepatocyte insufficiency. A decrease liver's ability store iron ions synthesize proteins provide an increase plasma contributes anemia not only cows, but also calves born from them.